Steer clear of the use of Promethazine HCl and Codeine Phosphate Oral Answer in adolescents 12 to eighteen many years of age who have other threat aspects which could enhance their sensitivity on the respiratory depressant consequences of codeine Unless of course the advantages outweigh the challenges.
The drug is excreted principally within the urine, mostly as inactive metabolites and compact amounts of totally free and conjugated morphine. Negligible amounts of codeine and its metabolites are located in the feces.
This merchandise might consist of inactive elements, which could bring about allergic reactions or other complications. Check with your pharmacist For additional specifics.
Consume plenty of fluids while you are employing this medication Except if in any other case directed by your medical doctor. The fluid will help loosen the mucus within your lungs.
Stimulation could possibly be obvious, especially in children and geriatric people. Convulsions may rarely come about. A paradoxical-kind response has become documented in little ones obtaining single doses of 75 mg to one hundred twenty five mg orally, characterized by hyperexcitability and nightmares.
Even though it helps many people, this medication contains a threat for abuse and may in some cases result in dependancy. This risk could be greater When you have a compound use problem (such as overuse of or addiction to drugs/Alcoholic beverages).
The next major adverse reactions are described, or explained in bigger element, in other sections:
You might build tolerance to this medication. Tolerance usually means that you're going to need an increased dose on the medication for suffering reduction. Tolerance is standard and is expected if you're taking this medication for a long period.
CONDITIONS OF USE: The data Within this database is meant to complement, not substitute for, the know-how and judgment of healthcare pros. The information will not be intended to deal with all attainable makes use of, Instructions, safeguards, drug interactions or adverse results, nor really should it's construed to indicate that utilization of a specific drug is safe, proper or productive for yourself or anyone else.
Give your treatment crew a summary of all medications you use. They'll show you how much medication to acquire. Do not choose a lot more medication than directed. Get crisis assistance at once Should you have challenges respiration.
Instruct nursing moms to speak to the newborn's medical doctor straight away if they discover these indicators and, if they can not reach the doctor instantly, to go ahead and take infant to an unexpected emergency place Promethazine codeine syrup or phone 911 (or nearby unexpected emergency expert services).
Kids must be supervised for the duration of bicycle riding and other probably hazardous pursuits to stay away from injury. Limit alcoholic beverages. Check with your doctor When you are employing cannabis (cannabis).
Daily life-threatening respiratory depression and Demise have transpired in children who obtained codeine. Codeine is subject to variability in metabolism centered upon CYP2D6 genotype (explained below), which can result in an increased publicity towards the Energetic metabolite morphine. Primarily based on put up-advertising reports, little ones young than twelve yrs previous appear to be a lot more susceptible to the respiratory depressant results of codeine, specially if there are chance variables for respiratory depression.
If this SPL incorporates inactivated NDCs outlined via the FDA initiated compliance action, they will be specified therefore.